Heparin: Clinical Indications and Strategies for Bleeding Risk Prevention

Authors

  • Nur Samsu

DOI:

https://doi.org/10.11594/jk-risk.05.1.1

Keywords:

heparin

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References

Qiu M, Huang S, Luo C, et al. Pharmacological and clinical application of heparin progress: an essential drug for modern medicine. Biomed Pharmacother. 2021;139:111561. DOI: https://doi.org/10.1016/j.biopha.2021.111561

Paschoa AF. Heparin: 100 years of pleiotropic effects. J Thromb Thrombolysis. 2016;41(4):636–43. DOI: https://doi.org/10.1007/s11239-015-1261-z

Alyahya R, Sudha T, Racz M, Stain SC, Mousa SA. Anti-metastasis efficacy and safety of non-anticoagulant heparin derivative versus low molecular weight heparin in surgical pancreatic cancer models. Int J Oncol. 2015;46(3):1225–31. DOI: https://doi.org/10.3892/ijo.2014.2803

Mulloy B, Hogwood J, Gray E, Lever R, Page CP. Pharmacology of heparin and related drugs. Pharmacol Rev. 2016;68(1):76–141. DOI: https://doi.org/10.1124/pr.115.011247

Lui PL, Tan SC, Goh PW, et al. Improving the safety of heparin usage by standardisation of practice. BMJ Open Qual. 2025;14(2):e002952. doi:10.1136/bmjoq-2024-002952. DOI: https://doi.org/10.1136/bmjoq-2024-002952

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Hirsh J, Anand SS, Halperin JL, et al. Guide to anticoagulant therapy: heparin: a statement for healthcare professionals from the American Heart Association. Circulation. 2001;103:2994–3018. DOI: https://doi.org/10.1161/01.CIR.103.24.2994

Stevens SM, Woller SC, Kreuziger LB, et al. An-tithrombotic therapy for VTE disease: second update of the CHEST guideline and expert pan-el report. Chest. 2021;160:e545–608. DOI: https://doi.org/10.1016/j.chest.2021.07.055

Bates DW, Cullen DJ, Laird N. Incidence of ad-verse drug events and potential adverse drug events. JAMA. 1995;274:29–34. doi:10.1001/jama.1995.03530010043033. DOI: https://doi.org/10.1001/jama.1995.03530010043033

Davies EC, Green CF, Taylor S, et al. Adverse drug reactions in hospital in-patients: a pro-spective analysis of 3695 patient-episodes. PLoS One. 2009;4:e4439. DOI: https://doi.org/10.1371/journal.pone.0004439

Piazza G, Nguyen TN, Cios D, et al. Anticoagula-tion-associated adverse drug events. Am J Med. 2011;124:1136–42. DOI: https://doi.org/10.1016/j.amjmed.2011.06.009

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Published

2025-10-31

How to Cite

Samsu, N. (2025). Heparin: Clinical Indications and Strategies for Bleeding Risk Prevention. Jurnal Klinik Dan Riset Kesehatan, 5(1), 1-2. https://doi.org/10.11594/jk-risk.05.1.1